INTRODUCTION Age-related cognitive disorders, including Alzheimer disease, are among the main causes of disability and dependence in older adults worldwide. High blood homocysteine levels (hyperhomocysteinemia) are a risk factor for diseases whose metabolism involves different B vitamins. Antioxidant vitamins provide a protective effect by mitigating oxidative stress generated by these diseases. Epidemiological studies have presented varying results on the relationships between blood levels of these vitamins and such cognitive disorders.
OBJECTIVE Evaluate the association of vitamin and homocysteine levels with mild cognitive impairment and Alzheimer disease in a group of Cuban older adults.
METHODS A cross-sectional study was conducted in Havana, Cuba, of 424 persons aged ≥65 years: 43 with Alzheimer disease, 131 with mild cognitive impairment, and 250 with no signs of cognitive impairment. Dementia was diagnosed using criteria of the International 10/66 Dementia Research Group and Diagnostic and Statistical Manual of Mental Disorders (DSM IV), and mild cognitive impairment was diagnosed using Petersen’s criteria. Blood levels of vitamins (thiamine, B-2, folate, B-12, C and A) and homocysteine were measured by standard procedures. Analysis of variance for continuous variables and percentage comparison tests for dichotomous variables were used to compare groups.
RESULTS Persons with Alzheimer disease presented significantly lower levels of vitamins B-2, C and A than healthy participants (p <0.05). Homocysteine levels were significantly higher in those with Alzheimer disease and mild cognitive impairment than in participants with no cognitive impairment (p <0.05). Statistically, levels of thiamine, folic acid, and vitamin B-12 were not significantly different across groups. Compared with those without cognitive impairment, prevalence rates (PR) in the Alzheimer group were significantly higher for hyperhomocysteinemia (PR = 3.26; 1.84–5.80) and deficiency of all B vitamins: thiamine (PR = 1.89; 1.04–3.43), B-2 (PR = 2.85; 1.54–5.26), folate (PR = 3.02; 1.53–5.95), B-12 (PR = 2.21; 1.17–4.19), vitamin C (PR = 3.88; 2.12–7.10) and A (PR = 5.47; 3.26–9.17). In mild cognitive impairment, prevalence rates were significantly higher for hyperhomocysteinemia (PR = 1.42; 1.08–1.87), vitamin B-2 deficiency (PR = 1.70; 1.24–2.32) and vitamin A deficiency (PR =1.88; 1.05–3.38).
CONCLUSIONS Hyperhomocysteinemia and various vitamin deficiencies are related to Alzheimer disease and mild cognitive impairment. Longitudinal studies are needed to further elucidate the relationship between different nutritional biomarkers and dementia. A better understanding of this relationship could provide a basis for therapeutic and preventive strategies.
KEYWORDS Vitamins, homocysteine, geriatrics, Alzheimer disease, cognitive impairment, Cuba
Las enfermedades crónicas no transmisibles se consideran la pandemia del siglo XXI y constituyen un desafío de alta prioridad para la salud pública; de ahí el creciente interés en la vigilancia de los factores de riesgo de las enfermedades crónicas. Cuba desarrolla la vigilancia de los factores de riesgo de forma descentralizada en cada uno de sus municipios como parte de la estrategia para enfrentar las enfermedades no transmisibles. No tiene precedentes en Cuba la vigilancia descentralizada con este nivel de detalle y diseñada expresamente para informar a los decisores en el municipio y la provincia. Se describe la metodología empleada para planificar y realizar la medición de los principales factores de riesgo en 12 municipios de 10 provincias, como parte del sistema nacional de vigilancia de Cuba. Los resultados han facilitado el uso oportuno de la información y la toma de decisiones basadas en pruebas a nivel local.
PALABRAS CLAVE: Sistema de vigilancia, factores de riesgo de enfermedades no transmisibles, encuestas de salud, métodos para la encuesta, Cuba
Chronic non-communicable diseases have been called the pandemic of the 21st century and constitute a high-priority public health challenge; hence growing interest in chronic disease risk factor surveillance. Cuba is implementing decentralized risk factor surveillance in each of its municipalities as part of a strategy to address non-communicable diseases. Decentralized surveillance with this level of detail and explicitly designed to inform municipal and provincial decisionmaking is unprecedented in Cuba. We describe the methodology for planning and implementing measurement of major risk factors in 12 municipalities in 10 provinces, as part of Cuba’s National Surveillance System. The results have facilitated timely use of information and evidence-based decisionmaking at the local level.
KEYWORDS: Surveillance system, non-communicable disease risk factors, health surveys, survey methods, Cuba
INTRODUCTION Acute myocardial infarction is one of the leading causes of death in the world. This is also true in Cuba, where no national-level epidemiologic studies of related mortality have been published in recent years.
OBJECTIVE Describe acute myocardial infarction mortality in Cuba from 1999 through 2008.
METHODS A descriptive study was conducted of persons aged ≥25 years with a diagnosis of acute myocardial infarction from 1999 through 2008. Data were obtained from the Ministry of Public Health’s National Statistics Division database for variables: age; sex; site (out of hospital, in hospital or in hospital emergency room) and location (jurisdiction) of death. Proportions, age- and sex-specific rates and age-standardized overall rates per 100,000 population were calculated and compared over time, using the two five-year time frames within the study period.
RESULTS A total of 145,808 persons who had suffered acute myocardial infarction were recorded, 75,512 of whom died, for a case-fatality rate of 51.8% (55.1% in 1999–2003 and 49.7% in 2004–2008). In the first five-year period, mortality was 98.9 per 100,000 population, falling to 81.8 per 100,000 in the second; most affected were people aged ≥75 years and men. Of Cuba’s 14 provinces and special municipality, Havana, Havana City and Camagüey provinces, and the Isle of Youth Special Municipality showed the highest mortality; Holguín, Ciego de Ávila and Granma provinces the lowest.
Out-of-hospital deaths accounted for the greatest proportion of deaths in both five-year periods (54.8% and 59.2% in 1999–2003 and 2004–2008, respectively).
CONCLUSIONS Although risk of death from acute myocardial infarction decreased through the study period, it remains a major health problem in Cuba. A national acute myocardial infarction case registry is needed. Also required is further research to help elucidate possible causes of Cuba’s high acute myocardial infarction mortality: cardiovascular risk studies, studies of out-of-hospital mortality and quality of care assessments for these patients.
KEYWORDS Acute myocardial infarction, ischemic heart disease, cardiovascular diseases, chronic disease, mortality, case-fatality, epidemiology, surveillance, registries, Cuba
Introduction Asthma affects some 300 million people worldwide and causes over 250,000 deaths each year. It is considered a global health problem due to associated high morbidity and mortality rates; disability in inadequately treated patients; years of potential life lost (YPLL); social costs; and impact on the lives of patients, their families and society. Environmental factors, including climatic conditions, are triggers. The 2004 Cuban National Survey on Asthma found a national prevalence of 13% (CI 9.3-16.8).
Objective Describe the relationship between climatic factors andasthma mortality in Cuba from 1989 to 2003.
Methods Data on deaths from asthma in Cuba were obtained frommedical death certificates. Crude and adjusted mortality rates werecalculated using the 1981 Cuban population as the standard population;the two-parameter exponential smoothing method was used fortrend and prediction analyses, with 95% confidence intervals (CI) forestimating mortality rates by age, sex and YPLL. ArcView softwareversion 3.3 was used to obtain, adjust, and represent models of meteorologicalvariables, and a bioclimatic atlas was included.
Results Asthma mortality rates increased in Cuba in the early 90sand then decreased and stabilized in recent years; a rate of 2 per100,000 population was predicted for 2008. For the period understudy, 61% of asthma-related deaths occurred in Cuba’s dry wintermonths (November-April). The meteorological variables related to riskof asthma mortality were: atmospheric pressure (997.7-1024.3 hPa),temperature (21.3-24.3oC), number of rainy days in the dry season(15.5-45.2 days), and cloudiness (2.99-5.51%). The provinces withthe highest risk of asthma mortality were: Havana City, Havana, Ciegode Ávila, and Camagüey.
Conclusions In Cuba, unfavorable weather conditions in some geographicareas can cause the death of asthmatic patients, althoughthese are not the only factors determining asthma mortality. Theasthma mortality rate is not alarmingly high and is expected to remainstable. Nevertheless, preventive measures must be maintained,particularly for women, who suffer excess mortality from the disease.Implementation of prevention strategies that take into considerationthe seasonal nature of asthma mortality is recommended.
Keywords Epidemiology, asthma, mortality, climate, asthma in women, respiratory tract diseases, bronchial diseases
