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Original Research
Prognostic Scale to Stratify Risk of Intrahospital Death in Patients with Acute Myocardial Infarction with ST-Segment Elevation
https://doi.org/10.37757/MR2020.V22.N3.10

INTRODUCTION The scales available to predict death and complications after acute coronary syndrome include angiographic studies and serum biomarkers that are not within reach of services with limited resources. Such services need specific and sensitive instruments to evaluate risk using accessible resources and information.

OBJECTIVE
Develop a scale to estimate and stratify the risk of intrahospital death in patients with acute ST-segment elevation myocardial infarction.

METHODS
An analytical observational study was conducted in a universe of 769 patients with acute ST-segment elevation myocardial infarction who were admitted consecutively to the Camilo Cienfuegos Provincial Hospital in Sancti Spíritus Province, Cuba, from January 2013 to March 2018. The fi nal study cohort included 667 patients, excluding 102 due to branch blocks, atrial fibrillation, drugs that prolong the QT interval, low life expectancy or history of myocardial infarction. The demographic variables of age, sex, skin color, classic cardiovascular risk factors, blood pressure, heart rate, blood glucose level, in addition to duration and dispersion of the QT interval with and without correction, left ventricular ejection fraction, and glomerular filtration rate were included in the analysis. Patients were categorized according to the Killip-Kimball Classification for degree of heart failure. A risk scale was constructed, the predictive ability of which was evaluated using the detectability index associated with an receiver-operator curve.

RESULTS
Seventy-seven patients died (11.5%). Mean blood glucose levels were higher among the deceased, while their systolic and diastolic blood pressure, left ventricular ejection fraction, and glomerular filtration rate were lower than those participants discharged alive. Relevant variables included in the scale were systolic blood pressure, Killip-Kimball class, cardiorespiratory arrest, glomerular filtration rate, corrected QT interval dispersion rate, left ventricular ejection fraction, and blood glucose levels. The variable with the best predictive ability was cardiorespiratory arrest, followed by a blood glucose level higher than 11.1 mmol/L. The scale demonstrated a great predictive ability with a detectability index of 0.92.

CONCLUSIONS The numeric scale we designed estimates and stratifies risk of death during hospitalization for patients with ST-segment elevation myocardial infarction and has good metric properties for predictive ability and calibration.

KEYWORDS ST-segment elevation myocardial infarction, mortality, risk assessment, Cuba

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ABSTRACT
INTRODUCTION The scales available to predict death and complications after acute coronary syndrome include angiographic studies and serum biomarkers that are not within reach of services with limited resources. Such services need specific and sensitive instruments to evaluate risk using  accessible resources and information.

OBJECTIVE Develop a scale to estimate and stratify the risk of intrahospital death in patients with acute ST-segment elevation myocardial infarction.

METHODS An analytical observational study was conducted in a universe of 769 patients with acute ST-segment elevation myocardial infarction who were admitted consecutively to the Camilo Cienfuegos Provincial Hospital in Sancti Spíritus Province, Cuba, from January 2013 to March 2018. The final study cohort included 667 patients, excluding 102 due to branch blocks, atrial fibrillation, drugs that prolong the QT interval, low life expectancy or history of myocardial infarction. The demographic variables of age, sex, skin color, classic cardiovascular risk factors, blood pressure, heart rate, blood glucose level, in addition to duration and dispersion of the QT interval with and without correction, left ventricular ejection fraction, and glomerular filtration rate were included in the analysis. Patients were categorized according to the Killip-Kimball Classification for degree of heart failure. A risk scale was constructed, the predictive ability of which was evaluated using the detectability index associated with an receiver-operator curve.

RESULTS Seventy-seven patients died (11.5%). Mean blood glucose levels were higher among the deceased, while their systolic and diastolic blood pressure, left ventricular ejection fraction, and glomerular filtration rate were lower than those participants discharged alive. Relevant variables included in the scale were systolic blood pressure, Killip-Kimball class, cardiorespiratory arrest, glomerular filtration rate, corrected QT interval dispersion, left ventricular ejection fraction, and blood glucose levels. The variable with the best predictive ability was cardiorespiratory arrest, followed by a blood glucose level higher than 11.1 mmol/L. The scale demonstrated a great predictive ability with a detectability index of 0.92.

CONCLUSIONS The numeric scale we designed estimates and stratifies risk of death during hospitalization for patients with ST-segment elevation myocardial infarction, and has good metric properties for predictive ability and calibration.

KEYWORDS ST-segment elevation myocardial infarction, mortality, risk assessment,
Cuba

INTRODUCTION
Cardiovascular disease is a global health problem. According to WHO, 17.8 million people worldwide died from cardiovascular disease in 2016, with 52.8% of these deaths attributable to ischemic heart disease.[1] Ischemic cardiopathy is the cardiovascular disease with the highest morbidity and mortality, and acute myocardial infarction (AMI) is the most serious and causes the most deaths.[2,3] According to a report from the American Heart Association, every 40 seconds, a US person suffers an AMI, although mortality from this cause decreased by 14.6% between 2006 and 2016 in the United States; however, approximately 550,000 first episodes and 200,000 recurrent episodes of acute myocardial infarction occur annually.[4]

In Europe, national records of countries in the European Society of Cardiology reveal intrahospital mortality at 4%–12%, while annual AMI mortality is approximately 10%.[2]

Eighty percent of deaths from AMI occur in low- and middle-income countries, where there is scarcity of therapeutic resources that meet international treatment guidelines.[5] The ability to predict the risks of complications and death with a scale that does not require angiography or serum biomarkers is an attractive prospect for these countries.

IMPORTANCE The scale designed permits estimation and stratification of intrahospital death risk for patients with ST-segment elevation myocardial infarction, using conventional clinical tools without the need to obtain angiographic studies or serum biomarkers in cardiac care units with limited resources

In Cuba, the mortality rate from heart disease in 2018 was 228.6 deaths per 100,000 population, with 63.3% of these deaths due to ischemic heart disease. For AMI, the mortality rate was 65.3 deaths per 100,000 population, of which 45.2% of deaths were due to ischemic heart disease. In Sancti Spíritus Province, in the center of the country, heart disease is also a health issue with a crude death rate of 237.9 deaths per 100,000 population and an age-adjusted death rate of 109.7 deaths per 100,000 population.[6]

Ischemic heart disease can be classified as an acute coronary syndrome, with or without ST-segment elevation, depending on the recording of at least two contiguous leads of the surface electrocardiogram (ECG).[5] In acute ST-segment elevation myocardial infarction, risk of complications and death is high despite advances in diagnosis and treatment of the condition. Prognosis for STEMI patients is related to the probability of developing short- or long-term complications and depends more on the state of the patient at the time of admission than on prior coronary risk factors.[2,5]

Efforts to develop models to quantify risk of complications or death for a patient with AMI using a scoring system started in the early 1950s,[7] and expanded as specialized coronary care units began to appear. In recent years, prediction models or algorithms have been developed that use serum biomarkers and clinical, electrocardiographic and angiographic variables to evaluate risk with greater precision and accuracy.[8] Despite the wide variety of proposed models[9,10] and the simplicity of some of them,[11,12] their use in clinical practice is limited, as they are highly dependent on availability of resources, primarily those relying on serum biomarkers.

High-income countries implement international treatment guidelines for AMI treatment[2,3] but these guidelines have limited applicability in low- and middle-income countries due to difficulty accessing more modern therapeutic resources. A 2014 study by Shimony[13] revealed that patients in low- and middle-income countries are less likely to receive treatment with percutaneous transluminal coronary angioplasty (PTCA) than those in high-income countries (4.9% compared to 45.6%), and that thrombolytic therapy was more common in low- and middle-income countries (72.5% compared to 38.9%). These disparities in AMI treatment are reflected in mortality rates that are higher in  low- and middle-income countries.[5] A study evaluating regional differences in AMI mortality at two years showed that the highest rates were reported in Latin America (7.4%) and the lowest in northern Europe (2.5%).[14] The differences in therapeutic options for these patients force low- and middle-income countries to look for risk stratification alternatives that allow them to decrease mortality while optimizing resources.

Risk estimation and stratification usually rely on analytical resources that combine the effects of different variables.[15] All risk scores designed thus far have their strengths and weaknesses, and their application is limited to the populations that served as the basis for their construction. The Global Registry of Acute Coronary Events (GRACE)[16] is the best-studied and validated instrument in the world,[17] but it contains elements that are not accessible for many low- and middle-income countries, such as measuring serum troponins.[7] The Thrombolysis in Myocardial Infarction (TIMI) Risk Score is an easy model to apply, but it was designed in the course of clinical trials, which has led its usefulness in daily practice to be called into question.[7,12]

A meta-analysis that included 42 validated studies on 31,625 patients recognized TIMI and GRACE as the only duly validated scores. The TIMI score has lower predictive ability (C = 0.77) than the GRACE (C = 0.82).[17]

Advances in AMI treatment allow providers to offer patients multiple therapeutic options depending on the severity of the disease and its prognosis. For this reason, there is still interest in determining the risks of complications and mortality with precision and accuracy. Considering the limitations of current algorithms and their application in coronary care units with limited resources, sensitive prognostic models must be developed to concentrate efforts and expenses on higher-risk patients, thereby improving risk-benefit and cost-effectiveness indicators.

The hospital where this research was conducted does not have the resources needed to perform modern reperfusion techniques,such as PTCA and use of fibrin-specific thrombolytic agents.[2] This further supports the need to more accurately estimate and stratify the initial risk of  complications and death in STEMI patients in the days following AMI.

The objective of this study was to create a scale to estimate and stratify risk of intrahospital mortality for STEMI patients.

METHODS
Design and population An observational analytical study was conducted on STEMI patients admitted consecutively to the coronary care unit at the Camilo Cienfuegos Provincial Hospital (HPCC) in Sancti Spíritus Province, Cuba, between January 1, 2013 and March 31, 2018. A total of 769 patients were registered, with 667 included and 102 excluded for the following reasons: 31 due to left bundle branch block of His, 19 due to prior atrial fibrillation, and 14 with medications that prolong the QT interval. These are all conditions that may make it difficult to take electrocardiographic measurements. Patients with conditions unrelated to the current ischemic event that considerably worsen prognosis were excluded from the study, including 23 patients with a history of myocardial infarction. Another 15 patients who were excluded due to a life expectancy of less than one year from non-cardiac conditions. Average age was 67.4 years (SD = 12.8). Of all participating patients, 441 (66.1%) were men and 226 (33.9%) were women.

In the absence of left ventricular hypertrophy and left bundle branch block, STEMI requires ≥2 mm of ST elevation (measured at J point) in two contiguous ECG leads in men ≥40 years old according to the ACC/AHA definition. A total of ≥2.5 mm is required in men <40 years old, and only 1.5 mm required in women of any age in the V2– V3 leads, or ≥1.0 mm in other leads.[2]

Study variables Age, sex, and skin color (white, brown, or black), were recorded, the latter variable determined by observers trained in this type of study. The following were considered cardiovascular risk factors: arterial hypertension (>140/90 mmHg), prior ischemic heart disease, hypercholesterolemia (cholesterol >6.71 mmol/L, according to established reference values), tobacco use, obesity (body mass index >30 kg/m2), history of diabetes mellitus and history of chronic obstructive pulmonary disease (COPD).[18] Systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) upon admission were considered clinical variables.

The degree of acute heart failure was evaluated using the Killip-Kimball classification[19] based on the following criteria:

Class I: No heart failure (no clinical signs of cardiac decompensation)
Class II: Heart failure: (rales in the lower half of lung fields, S3 gallop, and pulmonary venous hypertension)
Class III: Severe heart failure (frank pulmonary edema with crackling rales in all lung fields)
Class IV: Cardiogenic shock: (hypotension defined as systolic blood pressure <90 mmHg and evidence of peripheral vasoconstriction, such as oliguria, cyanosis and diaphoresis)

Values for blood glucose, leukocytes, creatinine, uric acid and total cholesterol were determined. Blood was drawn from the antecubital vein within 24 hours of the patient’s admission and was processed using a  Hitachi High-Technologies Corporation Cobas C311 Analyzer (Tokyo, Japan).

When possible, pharmacological thrombolysis was performed as a reperfusion procedure with 1,500,000 IU of Heberkinasa (recombinant streptokinase, Centro de Ingeniería Genética y Biotecnología, Cuba) administered intravenously.[20] This procedure was not performed on 307 patients for the following reasons: 127 (41.4%) due to long ischemic time (lapse from symptom onset to hospital arrival) >12 hours; 82 (26.7%) without precise initial diagnosis of AMI; 37 (12.1%) in cardiogenic shock; 21 (6.8%) with hemorrhagic stroke; 14 (4.6%) in prolonged cardiac arrest; 11 (3.6%) with known hemorrhagic disorders; 9 (2.9%) reporting a transient ischemic attack in the previous 6 months; and 6 (2.0%) with a history of  gastrointestinal hemorrhaging in the last month.

The infarction was localized via ECG performed on admission and classified according to the Bayés de Luna criteria (extensive anterior, mid-anterior, apical-anterior, septal, inferior, inferolateral, and lateral).[21] Among the complications studied were newly detected atrial fibrillation confirmed via surface ECG upon admission, high-grade and grade III atrioventricular blockage, recurring infarction (when signs and symptoms of acute coronary failure were repeated during admission after the first infarction) [22] and death.

The left ventricular ejection fraction (LVEF) was estimated using the Simpson biplane method[23] using a transthoracic echocardiogram with Aloka Alpha 5 equipment (Tokyo, Japan). The echocardiogram was performed when patients were hemodynamically stable with no signs of arterial hypotension, extreme bradycardia or arrhythmias.

Renal glomerular filtration rate (GFR) was calculated with the Cockcroft-Gault formula[24] using the obtained creatinine values. GFR [mL/min] = (140 – age [years]) x weight [kg] / Serum creatinine [mmol/L] x 0.81

For women, the expression above is multiplied by 0.85.

Electrocardiogram variables A 12-lead ECG was performed upon admission, before thrombolysis, and was repeated at 90 minutes. Electrocardiographic variables were taken from the first ECG and with patients who underwent thrombolysis, reperfusion signs were analyzed from the 90-minute ECG. ECGs were performed at a sweep speed of 25 mm/s with standardization set at 10 mm/mV, using a Cardiocid BB electrocardiograghy (Central Institute for Digital Research, Cuba)[25] with a bandpass filter restricting spectrum frequencies to 0.05–150 Hz and a comb filter for electrical hum at 60 Hz. Two observers used a magnifying glass to manually and independently measure the following parameters in all ECG leads:

QT interval (QTi): time in milliseconds from the start of QRS complex to the end of the T wave, defined as the point of ventricular repolarization of the T wave to the isoelectric line or the nadir between the T wave and the U wave if present.[26] This was measured in all the leads and the average calculated.
Corrected QTi (QTc), estimated using the Bazett’s formula.[27]
QT dispersion (QTd): QTi measured in the 12 ECG leads, calculating difference between maximum and minimum values.
Rate-corrected QTd (QTc d): QTi measured in the 12 ECG leads corrected with Bazett’s formula,[27] the difference calculated between maximum and minimum values.
ST elevation >1mV: Measured in all ECG leads in which ST elevation is observed from the baseline to the J point, and the TP segment is considered more isoelectric.
ST depression >1mV: Measured in all ECG leads in which the ST depression is observed from the baseline to the point of greatest ST-segment depression and the TP segment is considered more isodiphasic.
ST elevation in the aVR lead: ST-segment elevation is recorded at ≥1mm in this lead.

Data collection, processing and management Cardiologists performed initial patient evaluations and clinical followup. The hospital stay lasted five to seven days. Data was collected via hospital registration forms for the variables being studied. A database was created using the SPSS statistical package version 21.0 for Windows (IBM). Continuous data were  summarized with mean (m) and standard deviations (SD). For categorical data, absolute numbers and percentages were used. These descriptive statistics were calculated for both the living and deceased patients.

The heuristic for the creation of the scale is based on application of a classification model (classification tree) and a prediction model (binary logistic regression), the results of which were used to select the set of variables for later use in creating the scale, along with a criterion of parsimony to avoid information redundancy. The tree would provide evidence for choosing the optimal intercepts for each variable, and the regression model would be used to provide quantitative approximations the appropriate weights.

The number of categories (2 for cardiac arrest and 4 for the other variables) and the values on the scale were determined and assigned considering the criteria from the literature.[2,3,5,28,29] Categories were assigned between 0 and 3, except for cardiac arrest, which, due to its severity, was categorized as 0 (no) or 3 (yes). These categories and their significance are summarized below:

Cardiac arrest: 0, no; 3, yes
Blood glucose level: 0, ≤6.1 mmol/L; 1, 6.2–7.7 mmol/L; 2, 7.8–11.1 mmol/L; 3, >11.1 mmol/L
SBP: 0, >100 mmHg; 1, 90–100 mmHg; 2, 60–89 mmHg; 3, <60 mmHg
GFR: 0, ≥90 mL/min; 1, 60–89 mL/min; 2, 30–59 mL/min; 3, <30 mL/min
QTcd: 0, <40 ms; 1, 40–59 ms; 2, 60–79 ms; 3, ≥80 ms
Killip-Kimball class: 0, Class I; 3, Class IV
LVEF: 0, ≥55%; 1, 45–54%; 2, 30–44%; 3, <30%

The adjusted odds ratios (OR) were chosen as weights for the scale categories, rounding the results of the binary logistic regression model to the nearest whole number (except for the Killip-Kimball class which is rounded to the next highest whole number). Thus, the ORs are as follows: of QTcd = 2.18 ≈ 2; of GFR = 1.87 ≈ 2; of cardiac arrest = 3.17 ≈ 3; of SBP = 1.65 ≈ 2; of blood glucose level = 2.62 ≈ 3; of LVEF = 1.92 ≈ 2 and of Killip-Kimball class = 1.27 ≈ 2. The total score was obtained as a scalar product of the values of the variables, organized by their weights. The result is a scale we named EERIAM-HCC (in Spanish ‘Escala de Estratificación de Riesgo para el Infarto Agudo del Miocardio del Hospital Camilo Cienfuegos’), the Camilo Cienfuegos Hospital’s risk stratification scale for the AMI. It uses values between 0 (for a patient in the most favorable condition for all variables) and 48 (for a patient in the most unfavorable condition). After calculating their 10th, 25th, 50th, 75th, and 90th percentiles, this scale was then transformed into an ordinal scale with four levels:

Low risk: <25th percentile
Moderate risk: 25th–74th percentiles
High risk: 75th–89th percentiles
Extreme risk: ≥90th percentile

The discriminatory power of the EERIAM-HCC scale for intrahospital mortality is estimated using the receiveroperator curve (ROC) using estimates and the 95% confidence interval (CI) area under the curve. Calibration (the relationship between the observed and expected risk) was evaluated using the Hosmer-Lemeshow chisquare goodness-of-fit test. Traditionally, a value of p>0.05 associated with this test suggests an acceptable calibration of the model.

Ethics The study was approved by the hospital’s Research Ethics Committee. The design respected the principles of the Declaration of Helsinki,[30] the Norms of the Council of International Organizations of Medical Sciences (WHOCIOMS),[31] and the principles of good clinical practices. Each patient received a description of the research, including its risks and benefits. Written informed consent was obtained from patients, or from an immediate family member when patients were in extremely critical condition or had lost consciousness. The study design did not include manipulation of variables and followed the protocol established at the hospital for AMI treatment.  The tests and interventions were conducted by qualified personnel, with the necessary care taken to minimize risks in accordance with good clinical practice guidelines. Selection of laboratory methods followed the principles of maximum beneficence and non-maleficence in accordance with good laboratory practice guidelines.

Data were encrypted and names were not included in the databases, nor was any other information that could be used to identify participating patients, in order to respect their privacy and confidentiality.

RESULTS
Case fatality was 11.5% with 77 deceased patients, of which 49 (63.6%) were men. The average age was similar in both groups, as was distribution by sex (Table 1).

Results (Table 1) that distinguish the deceased patients from those who survived were notably higher values for the duration and dispersion of measured and corrected QTi, of the QRS complex and of blood glucose levels, as well as notably lower values of GFR and LVEF (Table 1).

Also notable are the differences between the two groups in frequency of cardiac arrest, atrial fibrillation, infarction recurrence, atrioventricular block, and diabetes, with this last factor being particularly high among the deceased.

Previous extensive apical myocardial infarction was much more frequent in the deceased patients, as was the number of cases in Killip-Kimball class IV (Table 1).

Proceeding through the nodes and branches of the regression tree (Figure 1), we see the following notable results:

Cardiac arrest is the event with the worst prognosis and the one that most distinguishes the response variable (alive or deceased). The risk ratio of death associated with cardiac arrest is >10 (52.2% for those with cardiac arrest and only 5% for those without cardiac arrest). In patients who did not suffer cardiac arrest (node 1) the risk increased 5% to 45.8% if initial blood glucose level was >11.1 mmol/L.

Only 3.3% of patients who did not suffer from cardiac arrest and whose blood glucose levels were <11.1 mmol/L died, but that risk quintupled if the patient was in Killip-Kimball class IV. If the patient was not in the Killip-Kimball class IV and their LVEF was >30%, risk of death was reduced to <1%.

On the right branch of the tree, which corresponds to the patients who suffered cardiac arrest, the risk is always higher than 50% except for those with QTcd <60 ms, for whom the risk is reduced. The adjusted ORs for covariates provided by the binary logistic regression model (Figure 2) provide an approximate measure of the relative importance of each variable as a predictor of intrahospital death, and are the basis for the creation of the scale established below.

New risk stratification scale for patients with STEMI is a quantitative scale that converts values between 0 and 48 points into an ordinal scale with four categories based on percentile distribution. Factors included in the scale were SBP, Killip-Kimball class, cardiac arrest, GFR, QTcd, LVEF and blood glucose level.

Most patients had between 10 and 19 points, which corresponds to moderate risk. None of the patients had the maximum number of points and only one deceased patient was close, with 44 points. A clear positive association is observed between the points on the scale and case fatality (Table 2).

DISCUSSION
The patients involved in the design of the EERIAM-HCC scale did not undergo PTCA, as established in the international treatment guides for myocardial infarction, as there is no hemodynamic service in the hospital’s coronary care unit.[2,3]

The new risk stratification scale for patients with STEMI combines variables that are easily acquired at a patient’s bedside, including QTi dispersion, which has been associated with greater severity of coronary artery disease,[32] higher incidence of ventricular arrhythmias,[33,34] and greater recurrence of infarction.[35] No other scale was found in the reviewed literature that included the QTi dispersion; however, QTi prolongation after STEMI was included in the scale designed by Rivera[36] in 2016.

Bordejevic[37] found that SBP <105 mmHg was associated with greater intrahospital mortality, even after PTCA had been performed. [37] SBP <100 mmHg is included as a predictor in both the TIMI[12] and GRACE[16] scales.

The importance of including GFR as a variable is based on indications that patients with chronic kidney disease and diminished kidney function have a greater risk of death and complications in the course of an AMI. Vavalle[38] studied 5244 STEMI patients and found a relationship between worsening renal function after PTCA and renal dysfunction in patients before their AMI. Gutiérrez and Martos Benítez[39] found that Cuban patients who were admitted with AMI and died had worse renal function based on their creatinine and GFR values. Granger[16] found that for every 88 μmol/L increase in creatinine, risk of death increased 19%–29% (95% CI 1.19–1.29) and risk of AMI increased 8%–16% (95% CI 1.08–1.16). Renal function is one of the variables included in the GRACE prognostic score.[16]

High blood glucose levels implies worse prognosis for those with acute coronary syndrome, in both diabetic and non-diabetic patients, and is included in the EPICOR scale.[40] Ding[41] found greater mortality in non-diabetic AMI patients when their blood glucose was >10.0 mmol/L. Stress hyperglycemia is common in AMI patients even without a prior diagnosis of diabetes mellitus.[2,3]

The five-year follow-up for a cohort of STEMI patients who were not diagnosed with diabetes mellitus showed that stress hyperglycemia implied a greater risk of death (relative risk, RR = 1.45; 95% CI 1.06–1.98; p = 0.021) and of readmission for heart failure (RR = 1.48; CI al 95% = 1.04–2.10; p = 0,031); however, in diabetic patients it did not imply a worse prognosis (mortality RR = 1.0; 95% CI 0.68–1.48; p = 0.996 or readmissions due to heart failure RR = 1.31; 95% CI 0.90–1.89; p = 0.154).[42] These findings may suggest a greater tolerance to hyperglycemia in diabetic patients. There are debates regarding what constitutes optimum control of blood sugar levels in AMI patients with acute myocardial ischemia.[43] Lacking sufficient evidence on the matter, the current guidelines recommend starting hypoglycemic treatment with insulin when blood glucose levels reach ≥10 mmol/L and avoiding hypoglycemia at levels <3.9 mmol/L.[2]

Mortality was much higher in patients with cardiac arrest, consistent with studies using the GRACE score[16] and ACTION-GWTG.[10] Cardiac arrest caused by ventricular arrhythmias occurs with greater frequency in patients with an ischemic time >12 hours before receiving medical care, incomplete revascularization, cardiogenic shock, infarctions that affect a large portion of the myocardial tissue, and preexisting arrhythmogenic substrate.[44]

In this study, Killip-Kimball Class I was most common in patients who were discharged alive and Class IV most common in deceased patients. A recent multicenter registry showed an association between heart failure and mortality at 30 days post-AMI in STEMI patients.[45] Cardiogenic shock (Killip-Kimball Class IV) is the main cause of death in myocardial infarction and presents as a complication in 6%–10% of all cases. Early death from cardiogenic shock is higher than 50%.[46] In a cohort of 112,668 survivors of myocardial infarction, 4.9% presented with cardiogenic shock, and a year later, readmissions and deaths from all causes among these patients increased (adjusted OR = 1.1; 95% CI 1.02–1.18).[47]

LVEF is a recognized predictor of long- and short-term complications after myocardial infarction.[29] In a multivariate prediction model for risk based on echocardiographic variables, LVEF was an independent predictor (hazard ratio = 1.45, 95% CI 1.02–2.08; p = 0.040) and the risk prognosis was inversely proportional to LVEF when it was <40%.[48] Schwaiger[49] demonstrated a greater incidence of complications in patients with LVEF <52% (hazard ratio = 2.57; 95% CI 1.1–6.2; p = 0.036) in STEMI patients with topographies that did not involve the anterior face.

The EERIAM-HCC scale developed in our study demonstrated a good discriminative ability (C = 0.92), higher than the C = 0.88 of the ACTION-GWTG score[10], which is consistent with results of this study in the predictive variables of cardiac arrest and the degree of heart failure, GFR and SBP—although this is based on a contemporary record of patients in the United States and includes troponins for estimating prognosis. TIMI,[12] which was used to predict death at 30 days post-AMI, has a C = 0.77 and is consistent with our EERIAM-HCC scale in the SBP and Killip-Kimball class variables. For predicting death at 6 months, GRACE[16] has C = 0.82 and includes among its variables renal function, as does our scale.  Conventionally, if the area under the curve has a C value greater than 0.9, the test is considered to have very good predictive power; C values between 0.7–0.9 are considered to have moderate predictive power; and values between 0.5–0.7, are considered to have poor predictive power.[50]

No significant differences were found between the frequency of cases observed and expected according to the Hosmer-Lemeshow goodness-of-fit test, indicating the scale is well calibrated.

One study limitation is that PTCA was never performed on patients in the cohort due to material limitations, and that the percentage of patients who undergo thrombolysis is low, which would explain the high mortality rate of the cohort. However, these results are useful for low- and middle-income countries requiring methods to provide quality medical care with limited resources. Another limitation in this first approximation is that the study did not analyze the outcomes or usefulness of the proposed scale in relation to additional variables such as age, sex and skin color, which should be considered in depth.

CONCLUSIONS
The relevant variables for the EERIAM-HCC scale to predict mortality and complications are cardiac arrest, blood glucose level, LVEF, QTcd, Killip-Kimball class, SBP and GFR.

The scale’s predictive ability and good calibration demonstrate its usefulness in stratifying risk of death for AMI patients with STsegment elevation myocardial infarction during the first seven days of hospitalization in coronary care units in Cuba and other settings where angiography and serum biomarkers are not readily available.

References
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THE AUTHORS
Ailed Elena Rodríguez-Jiménez (Corresponding author: ailedrj@infomed.sld.cu), physician with dual specialties in family medicine and cardiology, and a master’s degree in satisfactory longevity. Associate professor, Camilo Cienfuegos Provincial Hospital (HPCC), Sancti Spíritus, Cuba. https://orcid.org/0000-0001-8559-6867
Tessa Negrín-Valdés, physician with dual specialties in internal medicine and cardiology. Associate professor, HPCC, Sancti Spíritus, Cuba. https://orcid.org/0000-0001-5486-1373
Hugo Cruz-Inerarity, cardiologist. Teaching professor, HPCC, Sancti Spíritus, Cuba. https://orcid.org/0000-0001-8787-6520
Luis Alberto Castellano-Gallo, cardiologist. HPCC, Sancti Spíritus, Cuba. https://orcid.org/0000-0003-1959-0656
Elibet Chávez-González, cardiologist with a doctorate in medical sciences. Associate professor. HPCC, Sancti Spíritus, Cuba.
https://orcid.org/0000-0003-2246-2137

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Submitted: November 08, 2019
Approved: July 02, 2020
Disclosures: none

Rodríguez-Jiménez AE, Negrín Valdés T, Cruz-Inerarity H, Castellano-Gallo LA, Chávez-González E. Prognostic scale of stratify risk of intrahospital death in patients with acute myocardial infarction ST segment elevation. MEDICC Rev. 2020 Jul;22(3):p46–p53. https://doi.org/10.37757/MR2020.V22.N3.10

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